About MesoRD
MesoRD is a tool for stochastic simulation of reactions and diffusion [2]. In particular, it is an implementation of the Next Subvolume Method [3, 4], which is an exact method to simulate the Markov process corresponding to the reaction-diffusion master equation [5, 6, 7]. Following version 0.2.0 MesoRD also supports mean-field simulations. Starting with version 1.0, MesoRD supports high spatial resolution for bi-molecular reactions [8].
Download MesoRD
MesoRD source code is hosted at Sourceforge. Pre-built binaries are available for Windows.
Citing MesoRD
Please use reference [2] when citing MesoRD and reference [3] when citing the Next Subvolume Method.
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MATLAB Toolbox
Visualize your model results with our MATLAB toolbox.
References
- David Fange and Johan Elf (2006) Noise induced Min phenotypes in
E. coli. PLoS Comp. Biol.
- Johan Hattne, David Fange and Johan Elf (2005) Stochastic reaction-diffusion
simulation with MesoRD. Bioinfomatics
- Elf and Ehrenberg (2004) Spontaneous separation of bi-stable
biochemical systems into spatial domains of opposite phases. Systems Biolog.
Supplementary material:
Next Subvolume Method algorithm
- Elf et al. (2003) Mesoscopic reaction-diffusion in
intracellular signaling. SPIE
- Gardiner, C.: Handbook of stochastic Methods. Second edition
(Springer-Verlag. Berlin, 1985).
- Nicolis, G. and Prigogine, I.: Self-organization in
nonequilibrium systems. (John Wiley & sons. New York,
1977).
- Baras, F. and Mansour, M.M. (1997) Microscopic simulation of chemical
instabilities, Advances in Chemical Physics, 100:393-475.
- Fange D., Berg O.G., Sjöberg P., Elf J. (2010) Stochastic
reaction-diffusion kinetics in the microscopic limit. PNAS,
107:19820-5.
- Takahashi K, Tanase-Nicola S, Ten Wolde PR (2010) Spatio-temporal
correlations can drastically change the response of a MAPK
pathway. PNAS, 107:2473-2478.